Evaluation of the BRAHMS KRYPTOR thyroglobulin "mini-recovery" test in thyroid healthy subjects.
Horm Metab Res
; 44(7): 555-7, 2012 Jun.
Article
en En
| MEDLINE
| ID: mdl-22689210
The aim of the work was to compare the automated thyroglobulin (Tg) assay on the automated BRAHMS KRYPTOR platform (hTG KRYPTOR) to the established BRAHMS Tg Plus immunoradiometric assay for the measurement of Tg levels and regular Tg recovery rates and to assess a recovery test using a low Tg concentration of 10 µg/l ("mini-recovery") in samples with a native Tg level of <10 µg/l. Tg levels and recovery rates, as well as the mini-recovery, were determined in 208 serum samples from thyroid-healthy patients using both assays. The reference ranges for the Tg-Plus assay are 2.0-51.0 µg/l for Tg levels and 81.5-108% for recovery rates at 100 µg/l. The reference ranges for hTG KRYPTOR are 2.4-47.8 µg/l for Tg, 83.3-110.4% for a conventional recovery with 80 µg/l in Tg levels ≥ 10.0 µg/l (n=121) and 94.4-122.9% for the mini-recovery with Tg <10.0 µg/l (n=87). The correlation between the Tg-Plus and hTG KRYPTOR is excellent for Tg (r2=0.95; p<0.001), but not significant for recovery rates. Tg levels determined using the KRYPTOR Tg assay are clinically comparable to the conventional Tg-Plus assay. New features of the KRYPTOR assay such as the ability to perform a "mini-recovery" still require further study before clinical use.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Tiroglobulina
/
Glándula Tiroides
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Salud
/
Técnicas y Procedimientos Diagnósticos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Límite:
Adolescent
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Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Horm Metab Res
Año:
2012
Tipo del documento:
Article
País de afiliación:
Alemania
Pais de publicación:
Alemania