Sesquiterpenes from the leaves of Laurus nobilis L.

Julianti, Elin; Jang, Kyoung Hwa; Lee, Sooryun; Lee, Dongha; Mar, Woongchon; Oh, Ki-Bong; Shin, Jongheon

Julianti, Elin; Jang, Kyoung Hwa; Lee, Sooryun; Lee, Dongha; Mar, Woongchon; Oh, Ki-Bong; Shin, Jongheon.

Afiliación

Julianti E; Natural Products Research Institute, College of Pharmacy, Seoul National University, San 56-1, Sillim, Gwanak, Seoul 151-742, Republic of Korea.

Phytochemistry ; 80: 70-6, 2012 Aug.

Article en En | MEDLINE | ID: mdl-22683316

RESUMEN

Ten sesquiterpenes, together with 12 known compounds were isolated from leaves of Laurus nobilis L. Based on spectroscopic analyses, the 10 compounds were determined to be eudesmane lactones and their corresponding methyl esters. Most of these compounds exhibited moderate-to-significant cytotoxicity towards K562 leukemia cells. One compound had a higher cytotoxicity than doxorubicin, while other compounds had moderate to no activity.

Asunto(s)

Antineoplásicos/química; Antineoplásicos/farmacología; Laurus/química; Hojas de la Planta/química; Sesquiterpenos/química; Sesquiterpenos/farmacología; Antineoplásicos/aislamiento & purificación; Humanos; Células K562; Espectroscopía de Resonancia Magnética; Sesquiterpenos/aislamiento & purificación

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Sesquiterpenos / Hojas de la Planta / Laurus / Antineoplásicos Límite: Humans Idioma: En Revista: Phytochemistry Año: 2012 Tipo del documento: Article Pais de publicación: Reino Unido

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