Relationship of the behavioral effects of aprophen, atropine and scopolamine to antagonism of the behavioral effects of physostigmine.
Pharmacol Biochem Behav
; 37(1): 117-22, 1990 Sep.
Article
en En
| MEDLINE
| ID: mdl-2263653
Behavioral effects of aprophen, atropine and scopolamine, in rats, were examined under a multiple schedule of food presentation and at different injection-test times. The effects of the varied treatments were compared to the ability of the drugs, under identical conditions, to prevent the behavioral effects of the anticholinesterase, physostigmine. Potencies of the antagonists to decrease response rates varied across three log units. All three antagonists produced dose-related attenuation of the response suppressant effects of physostigmine. In general, aprophen was a better antagonist than scopolamine or atropine. It blocked behavioral effects of physostigmine across a wider range of doses than the other compounds, and did so with less behavioral disruption. Although substantial differences between the three antagonists were observed, the behavioral effects of all three antagonists (when administered alone) were positively correlated with their efficacy as antagonists of the response suppressant effects of physostigmine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Parasimpatolíticos
/
Fenilpropionatos
/
Fisostigmina
/
Atropina
/
Escopolamina
/
Condicionamiento Operante
Límite:
Animals
Idioma:
En
Revista:
Pharmacol Biochem Behav
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Estados Unidos