Effects of compound danshen tablets on spatial cognition and expression of brain beta-amyloid precursor protein in a rat model of Alzheimer's disease.
J Tradit Chin Med
; 32(1): 63-6, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22594104
OBJECTIVE: To observe the effects of Compound Danshen Tablets (CDST) on spatial cognition and expression of brain b-amyloid precursor protein (beta-APP) in a rat model of Alzheimer's disease. METHODS: The rat model of Alzheimer's disease (AD) was established using D-galactose to cause subacute aging combined with Meynert nucleus damage. Rat behavior was monitored using the Morris water maze, and the expression of beta-APP in rat brain tissue was detected via immunohistochemistry. RESULTS: CDST significantly improved spatial cognition and decreased beta-APP expression in the cortex and hippocampus (P < 0.05, P < 0.01). CONCLUSIONS: CDST can significantly improve spatial cognition in a rat model of AD. This observation is possibly related to a reduction in beta-APP expression in the rat brain.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Encéfalo
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Medicamentos Herbarios Chinos
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Precursor de Proteína beta-Amiloide
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Cognición
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Salvia miltiorrhiza
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Enfermedad de Alzheimer
Límite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
J Tradit Chin Med
Año:
2012
Tipo del documento:
Article
País de afiliación:
China
Pais de publicación:
China