Functional graph alterations in schizophrenia: a result from a global anatomic decoupling?
Pharmacopsychiatry
; 45 Suppl 1: S57-64, 2012 May.
Article
en En
| MEDLINE
| ID: mdl-22565236
During rest, the brain exhibits slow hemodynamic fluctuations (<0.1 Hz) that are correlated across spatially segregated brain regions, defining functional networks. Resting-state functional networks of people with schizophrenia were found to have graph properties that differ from those of control subjects. Namely, functional graphs from patients exhibit reduced small-worldness, increased hierarchy, lower clustering, improved efficiency and greater robustness. Notably, most of these parameters correlate with patients' cognitive performance.To test if a brain-wide coupling deficit could be at the origin of such network reorganization, we use a model of resting-state activity where the coupling strength can be manipulated. For a range of coupling values, the simulated functional graphs obtained were characterized using graph theory.For a coupling range, simulated graphs shared properties of healthy resting-state functional graphs. On decreasing the coupling strength, the resultant functional graphs exhibited a topological reorganization, in the same way as described in schizophrenia.This work shows how complex functional graph alterations reported in schizophrenia can be accounted for by a decrease in the structural coupling strength. These results are corroborated by reports of lower white matter density in schizophrenia.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Psicología del Esquizofrénico
/
Red Nerviosa
Tipo de estudio:
Prognostic_studies
Límite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Pharmacopsychiatry
Año:
2012
Tipo del documento:
Article
País de afiliación:
España
Pais de publicación:
Alemania