The impact of Hodgkin's disease on the immune system.

Slivnick, D J; Ellis, T M; Nawrocki, J F; Fisher, R I

Slivnick, D J; Ellis, T M; Nawrocki, J F; Fisher, R I.

Afiliación

Slivnick DJ; Section of Hematology/Oncology, Loyola University Stritch School of Medicine, Maywood, IL.

Semin Oncol ; 17(6): 673-82, 1990 Dec.

Article en En | MEDLINE | ID: mdl-2251514

RESUMEN

Patients with Hodgkin's disease, at presentation or in remission, exhibit a persistent defect in cellular immunity. Natural killer cell mediated cytotoxicity is depressed in untreated patients. Humoral immune function is transiently reduced following treatment. The cellular immune defect appears to be the result of enhanced sensitivity to suppressor monocytes and T-suppressor cells, in addition to abnormal interleukin-2 production. Patients with advanced disease have an inherent T-lymphocyte defect. Reed-Sternberg cells function as antigen-presenting cells for mitogen-induced and mixed lymphocyte T-cell proliferation.

Asunto(s)

Enfermedad de Hodgkin/inmunología; Formación de Anticuerpos; Enfermedad de Hodgkin/complicaciones; Humanos; Inmunidad Celular

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de Hodgkin Límite: Humans Idioma: En Revista: Semin Oncol Año: 1990 Tipo del documento: Article Pais de publicación: Estados Unidos

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