CD11c decrease in mouse thymic dendritic cells after vanadium inhalation.
J Immunotoxicol
; 9(4): 374-80, 2012.
Article
en En
| MEDLINE
| ID: mdl-22512508
Vanadium (V) is a transition metal found in air adsorbed onto suspended particles. As a result, urban populations are often exposed to this element as a constituent of particulate matter (PM). One aspect of the myriad toxicities that might arise from these exposures is altered immune responses. Previous reports from the laboratory reported modifications in splenic architecture - with germinal center hyperplasia and a suppressed humoral immune response - in mice that had been exposed to vanadium agents via inhalation. This paper reports a decrease in the presence of the CD11c surface marker on mouse thymic dendritic cells (DC) as a result of host exposure to vanadium (here, in the form of vanadium pentoxide; V(2)O(5)) over a period of 4 weeks. All results were obtained using immunohistochemistry and flow cytometry. It is surmised that this decrease might induce a dysfunction, including possible negative selection of T-cells, which could increase the presence of autoreactive clones in the exposed host. Such an outcome could, in turn, increase the risk for development of autoimmune reactions in different organs specifically, and of autoimmune diseases in general in these V-exposed hosts.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
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Timo
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Vanadio
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Células Dendríticas
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Antígeno CD11c
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Contaminantes Atmosféricos
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Exposición a Riesgos Ambientales
Límite:
Animals
Idioma:
En
Revista:
J Immunotoxicol
Asunto de la revista:
ALERGIA E IMUNOLOGIA
/
TOXICOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Reino Unido