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Nodal expression and detection in cancer: experience and challenges.
Strizzi, Luigi; Hardy, Katharine M; Kirschmann, Dawn A; Ahrlund-Richter, Lars; Hendrix, Mary J C.
Afiliación
  • Strizzi L; Children's Memorial Research Center, Cancer Biology and Epigenomics Program, Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60614, USA.
Cancer Res ; 72(8): 1915-20, 2012 Apr 15.
Article en En | MEDLINE | ID: mdl-22508696
Nodal is a TGF-ß-related embryonic morphogen that is expressed in multiple human cancers. Detection of Nodal expression in these tissues can be challenging if issues related to Nodal transcription and protein processing are not considered. Here, we discuss certain characteristics related to Nodal expression and function and how these can facilitate acquisition and interpretation of expression data, contributing to our understanding of the potential role of Nodal in human cancer. We also discuss how Nodal could be exploited clinically as a novel biomarker for cancer progression and therapeutic target.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Nodal / Neoplasias Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Cancer Res Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteína Nodal / Neoplasias Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Cancer Res Año: 2012 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos