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Evaluation of Biocompatibility of Alloplastic Materials: Development of a Tissue Culture In Vitro Test System.
Gerullis, Holger; Georgas, Evangelos; Eimer, Christoph; Goretzki, Peter E; Lammers, Bernhard J; Klosterhalfen, Bernd; Boros, Mihaly; Wishahi, Mohamed; Heusch, Gerd; Otto, Thomas.
Afiliación
  • Gerullis H; Consultant, Department of Urology, Lukas Hospital, Neuss, Germany.
  • Georgas E; Department of Urology, Lukas Hospital, Neuss, Germany.
  • Eimer C; Department of Urology, Lukas Hospital, Neuss, Germany.
  • Goretzki PE; Department of General Surgery, Lukas Hospital, Neuss, Germany.
  • Lammers BJ; Department of General Surgery, Lukas Hospital, Neuss, Germany.
  • Klosterhalfen B; German Centre for Implant-Pathology, Duren, Germany.
  • Boros M; Department of Experimental Surgery, University of Szeged, Szeged, Hungary.
  • Wishahi M; Department of Urology, Theodor Bilharz Research Institute, Cairo, Egypt.
  • Heusch G; Institute for Pathophysiology, University of Essen, Essen, Germany.
  • Otto T; Department of Urology, Lukas Hospital, Neuss, Germany, Oncologist, West German Cancer Center, University of Essen, Essen, Germany.
Surg Technol Int ; 21: 21-7, 2011 Dec.
Article en En | MEDLINE | ID: mdl-22504966
Optimized biocompatibility is a major requirement for alloplastic materials currently applied in surgical approaches for hernia, incontinence, and prolapse situations. Tissue ingrowth/adherence and formation of connective tissue seem to have important influence in mesh incorporation at the implant site. In an in vitro approach we randomly investigated 7 different mesh types currently used in surgeries with various indications with regard to their adherence performance. Using a tissue culture approach, meshes were incubated with tissue representative of fibroblasts, muscle cells, and endothelial cells originating from 10 different patients. After 6 weeks, the meshes were assessed microscopically and a ranking of their adherence performance was established. Tissue culture was successful in 100% of the probes. We did not remark on interindividual differences concerning the growth and adherence performance after incubation with the different meshes in the investigated 10 patients. The ranking was consistent in all patients. In this test system, PVDF Dynamesh® (FEG Textiltechnik, Aachen, Germany) was the mesh with the best growth-in score. The test system was feasible and reproducible. Pore size seems to be a predictor of adherence performance. The test system may be a helpful tool for further investigations, and the predictive value should be assessed in further in vitro and in vivo experiments.
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Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Surg Technol Int Año: 2011 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
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Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Surg Technol Int Año: 2011 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos