Alkyne and reversible nitrile activation: N,N'-diamidocarbene-facilitated synthesis of cyclopropenes, cyclopropenones, and azirines.
J Am Chem Soc
; 134(14): 6116-9, 2012 Apr 11.
Article
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| MEDLINE
| ID: mdl-22463070
We report the synthesis of a variety of diamidocyclopropenes by combining an isolable and readily accessible N,N'-diamidocarbene (DAC) with a range of alkynes (nine examples, 68-97% yield). Subsequent hydrolysis of selected cyclopropenes afforded the corresponding cyclopropenones or α,ß-unsaturated acids, depending on the reaction conditions. In addition, the combination of a DAC with alkyl or aryl nitriles was found to form 2H-azirines in a reversible manner (four examples, K(eq) = 4-72 M(-1) at 30 °C in toluene).
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Am Chem Soc
Año:
2012
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Estados Unidos