Potential of Novel EPO Derivatives in Limb Ischemia.

Joshi, Dhiraj; Tsui, Janice; Yu, Rebekah; Shiwen, Xu; Selvakumar, Sadasivam; Abraham, David J; Baker, Daryll M

Joshi, Dhiraj; Tsui, Janice; Yu, Rebekah; Shiwen, Xu; Selvakumar, Sadasivam; Abraham, David J; Baker, Daryll M.

Afiliación

Joshi D; Vascular Unit, Division of Surgery and Interventional Science, Royal Free Hospital, University College London (Royal Free Campus), Pond Street, London NW3 2QG, UK.

Cardiol Res Pract ; 2012: 213785, 2012.

Article en En | MEDLINE | ID: mdl-22462027

RESUMEN

Erythropoietin (EPO) has tissue-protective properties, but it increases the risk of thromboembolism by raising the haemoglobin concentration. New generation of EPO derivatives is tissue protective without the haematopoietic side effects. Preclinical studies have demonstrated their effectiveness and safety. This paper summarizes the development in EPO derivatives with emphasis on their potential use in critical limb ischaemia.

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cardiol Res Pract Año: 2012 Tipo del documento: Article Pais de publicación: Estados Unidos

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