The effects of taurine on permethrininduced cytogenetic and oxidative damage in cultured human lymphocytes.
Arh Hig Rada Toksikol
; 63(1): 27-34, 2012 Mar.
Article
en En
| MEDLINE
| ID: mdl-22450203
Permethrin (PM) is a common pyrethroid pesticide used to control pests in agriculture, forestry, horticulture, health care, homes, and textile industry. It is confirmed as a strong mutagen in animals and humans. Taurine (TA) is an amino acid found in mammalian tissues that protects the cell against DNA damage. In this study, we investigated whether supplementation of human lymphocyte cultures with TA (in the concentrations of 25 µg mL-1, 50 µg mL-1 and 100 µg mL-1) provided any protection against PM toxicity applied in the concentration of 200 µg mL-1. Genotoxicity was assessed using the micronucleus (MN) and sister chromatid exchanges (SCE) tests. In addition, we measured the total antioxidant capacity (TAC) and total oxidative stress (TOS) levels in the plasma to determine oxidative effects. PM increased SCE and MN levels and altered TAC and TOS levels. TA alone did not affect SCE and MN levels compared to controls, regardless of the concentration applied. In addition, it increased TAC levels without changing TOS levels. Moreover, it significantly buffered the negative cytogenetic and oxidative effects induced by PM in a clear dose-dependent manner. In conclusion, this study is the first to evidence the beneficial effects of TA against PM-induced DNA and oxidative damages in vitro.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Intercambio de Cromátides Hermanas
/
Taurina
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Linfocitos
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Pruebas de Micronúcleos
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Estrés Oxidativo
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Permetrina
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Insecticidas
Límite:
Adult
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Female
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Humans
Idioma:
En
Revista:
Arh Hig Rada Toksikol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Croacia