ISCOMATRIX: a novel adjuvant for use in prophylactic and therapeutic vaccines against infectious diseases.
J Med Microbiol
; 61(Pt 7): 935-943, 2012 Jul.
Article
en En
| MEDLINE
| ID: mdl-22442293
The ISCOMATRIX adjuvant has antigen delivery and presentation properties as well as immunomodulatory capabilities, which combine to provide enhanced and accelerated immune responses. The responses are broad, including a range of subclasses of antibodies as well as CD4(+) and CD8(+) T-cells. A range of ISCOMATRIX vaccines (ISCOMATRIX adjuvant combined with antigen) have now been tested in clinical trials and have been shown to be generally safe and well tolerated as well as immunogenic, generating both antibody (Ab) and T-cell responses. The mechanisms by which ISCOMATRIX adjuvant facilitates its immune effects are the scope of significant study and indicate that ISCOMATRIX adjuvant (i) rapidly traffics antigen into the cytosol of multiple dendritic cell subsets, (ii) induces the induction of an array of cytokines and chemokines and (iii) links the innate and adaptive immune responses in vivo in a Toll-like-receptor-independent but MyD88-dependent manner. These data highlight the clinical utility of ISCOMATRIX adjuvant in the development of prophylactic and therapeutic vaccines for infectious disease.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fosfolípidos
/
Saponinas
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Vacunas
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Adyuvantes Inmunológicos
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Colesterol
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Enfermedades Transmisibles
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Vacunación
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Inmunoterapia
Límite:
Humans
Idioma:
En
Revista:
J Med Microbiol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Australia
Pais de publicación:
Reino Unido