Synthesis of amino core compounds of galactosyl phytosyl ceramide analogs for developing iNKT-cell inducers.
Molecules
; 17(3): 3058-81, 2012 Mar 12.
Article
en En
| MEDLINE
| ID: mdl-22410417
1-Aminophytosphingosine and 6-aminogalactosyl phytosphingosine were prepared in 61% and 40% yield libraries with 44 carboxylic acids showed that a 4-butylbenzoic acid-derived product exe, respectively. Glycosylation using benzoyl-protected lipid resulted in better a-selectivity for ceramide analogs, but the yield was less than that obtained with benzyl moieties. Screening the amide rted less cytotoxicity. These analogs were purified for validation of immunological potencies and the a-GalCer analog but not the sphingosine analog stimulated human iNKT cell population.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esfingosina
/
Bibliotecas de Moléculas Pequeñas
/
Células T Asesinas Naturales
/
Galactosilceramidas
/
Aminas
Límite:
Humans
Idioma:
En
Revista:
Molecules
Asunto de la revista:
BIOLOGIA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Taiwán
Pais de publicación:
Suiza