Orexins increase penicillin-induced epileptic activity.
Peptides
; 34(2): 419-22, 2012 Apr.
Article
en En
| MEDLINE
| ID: mdl-22394654
Orexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Conducta Animal
/
Neuropéptidos
/
Corteza Cerebral
/
Péptidos y Proteínas de Señalización Intracelular
/
Epilepsia
Límite:
Animals
Idioma:
En
Revista:
Peptides
Año:
2012
Tipo del documento:
Article
País de afiliación:
Turquía
Pais de publicación:
Estados Unidos