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Antibacterial bisabolane-type sesquiterpenoids from the sponge-derived fungus Aspergillus sp.
Li, Dan; Xu, Ying; Shao, Chang-Lun; Yang, Rui-Yun; Zheng, Cai-Juan; Chen, Yi-Yan; Fu, Xiu-Mei; Qian, Pei-Yuan; She, Zhi-Gang; Voogd, Nicole J de; Wang, Chang-Yun.
Afiliación
  • Li D; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • Xu Y; KAUST Global Academic Partnership Program, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
  • Shao CL; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • Yang RY; Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education, School of Chemistry & Chemical Engineering, Guangxi Normal University, Guilin 541004, China.
  • Zheng CJ; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • Chen YY; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • Fu XM; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
  • Qian PY; KAUST Global Academic Partnership Program, Division of Life Science, The Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
  • She ZG; School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China.
  • Voogd NJ; Netherlands Centre for Biodiversity Naturalis, P.O. Box 9517, Leiden 2300 RA, The Netherlands.
  • Wang CY; Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Mar Drugs ; 10(1): 234-241, 2012 Jan.
Article en En | MEDLINE | ID: mdl-22363233
Four new bisabolane-type sesquiterpenoids, aspergiterpenoid A (1), (-)-sydonol (2), (-)-sydonic acid (3), and (-)-5-(hydroxymethyl)-2-(2',6',6'-trimethyltetrahydro-2H- pyran-2-yl)phenol (4) together with one known fungal metabolite (5) were isolated from the fermentation broth of a marine-derived fungus Aspergillus sp., which was isolated from the sponge Xestospongia testudinaria collected from the South China Sea. Four of them (1-4) are optically active compounds. Their structures and absolute configurations were elucidated by using NMR spectroscopic techniques and mass spectrometric analysis, and by comparing their optical rotations with those related known analogues. Compounds 1-5 showed selective antibacterial activity against eight bacterial strains with the MIC (minimum inhibiting concentrations) values between 1.25 and 20.0 µM. The cytotoxic, antifouling, and acetylcholinesterase inhibitory activities of these compounds were also examined.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Aspergillus / Sesquiterpenos / Antibacterianos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poríferos / Aspergillus / Sesquiterpenos / Antibacterianos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza