Comparison of single-dose and steady-state nadolol plasma concentrations.
Pharm Res
; 7(9): 953-6, 1990 Sep.
Article
en En
| MEDLINE
| ID: mdl-2235896
The pharmacokinetics of nadolol have been previously reported to be linear between single and steady-state dosing. Data from a study in our laboratory suggested greater than expected beta-blockade with nadolol at steady state. Because the early potency studies were single-dose studies, we hypothesized there was a nonlinearity in nadolol pharmacokinetics which produced higher than expected plasma concentrations at steady state. Six normal volunteers from the previous study (steady state) volunteered to participate in the single-dose study. Plasma concentrations were determined for 24 hr following a single dose of nadolol, 80 mg. A simple, inexpensive, and accurate method for determination of nadolol in plasma or serum by HPLC with fluorometric detection is described. The AUC0-tau at steady state was greater than the AUC0-infinity following a single dose in five of the six subjects. The mean ratio of AUCss/AUCsd was 2.54. This value would be unity in the presence of linear pharmacokinetics. We conclude that the principle of superposition is not applicable for nadolol.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nadolol
Límite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Pharm Res
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Estados Unidos