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Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
Rohrmann, S; Grote, V A; Becker, S; Rinaldi, S; Tjønneland, A; Roswall, N; Grønbæk, H; Overvad, K; Boutron-Ruault, M C; Clavel-Chapelon, F; Racine, A; Teucher, B; Boeing, H; Drogan, D; Dilis, V; Lagiou, P; Trichopoulou, A; Palli, D; Tagliabue, G; Tumino, R; Vineis, P; Mattiello, A; Rodríguez, L; Duell, E J; Molina-Montes, E; Dorronsoro, M; Huerta, J-M; Ardanaz, E; Jeurnink, S; Peeters, P H M; Lindkvist, B; Johansen, D; Sund, M; Ye, W; Khaw, K-T; Wareham, N J; Allen, N E; Crowe, F L; Fedirko, V; Jenab, M; Michaud, D S; Norat, T; Riboli, E; Bueno-de-Mesquita, H B; Kaaks, R.
Afiliación
  • Rohrmann S; Division of Cancer Epidemiology and Prevention, Institute of Social and Preventive Medicine, University of Zurich, Hirschengraben 84, Zürich 8001, Switzerland. sabine.rohrmann@ifspm.uzh.ch
Br J Cancer ; 106(5): 1004-10, 2012 Feb 28.
Article en En | MEDLINE | ID: mdl-22315049
BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR=1.21, 95% CI 0.75-1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR=1.00, 95% CI 0.66-1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR=1.22, 95% CI 0.75-1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR=1.72, 95% CI 1.05-2.83; P-interaction=0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Factor I del Crecimiento Similar a la Insulina / Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Cancer Año: 2012 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Factor I del Crecimiento Similar a la Insulina / Proteína 3 de Unión a Factor de Crecimiento Similar a la Insulina Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Europa Idioma: En Revista: Br J Cancer Año: 2012 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Reino Unido