Isolation and characterization of a novel H9N2 influenza virus in Korean native chicken farm.
Avian Dis
; 55(4): 724-7, 2011 Dec.
Article
en En
| MEDLINE
| ID: mdl-22313001
An outbreak of avian influenza, caused by an H9N2 low-pathogenic avian influenza virus (AIV), occurred in a chicken farm and caused severe economic losses due to mortality and diarrhea. AIV was isolated and identified in a sample from an affected native Korean chicken. Genetic analysis of the isolate revealed a high sequence similarity to genes of novel reassortant H9N2 viruses isolated from slaughterhouses and live bird markets in Korea in 2008 and 2009. Animal challenge studies demonstrated that the replication kinetics and pathogenicity of the isolate were considerably altered due to adaptation in chickens. Vaccine protection studies indicated that commercial vaccine was not able to prevent virus shedding and clinical disease when chickens were challenged with the isolate. These results suggest that the novel H9N2 virus possesses the capacity to replicate efficiently in the respiratory system against vaccination and to cause severe disease in domestic chickens. The results also highlight the importance of appropriate updating of vaccine strains, based on continuous surveillance data, to prevent the possibility of a new H9N2 epidemic in Korea.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Pollos
/
Subtipo H9N2 del Virus de la Influenza A
/
Gripe Aviar
Límite:
Animals
País/Región como asunto:
Asia
Idioma:
En
Revista:
Avian Dis
Año:
2011
Tipo del documento:
Article
Pais de publicación:
Estados Unidos