Your browser doesn't support javascript.
loading
Changing trends in antimicrobial resistance and serotypes of Streptococcus pneumoniae isolates in Asian countries: an Asian Network for Surveillance of Resistant Pathogens (ANSORP) study.
Kim, So Hyun; Song, Jae-Hoon; Chung, Doo Ryeon; Thamlikitkul, Visanu; Yang, Yonghong; Wang, Hui; Lu, Min; So, Thomas Man-Kit; Hsueh, Po-Ren; Yasin, Rohani M; Carlos, Celia C; Pham, Hung Van; Lalitha, M K; Shimono, Nobuyuki; Perera, Jennifer; Shibl, Atef M; Baek, Jin Yang; Kang, Cheol-In; Ko, Kwan Soo; Peck, Kyong Ran.
Afiliación
  • Kim SH; Asia Pacific Foundation for Infectious Diseases, Seoul, South Korea.
Antimicrob Agents Chemother ; 56(3): 1418-26, 2012 Mar.
Article en En | MEDLINE | ID: mdl-22232285
Antimicrobial resistance in Streptococcus pneumoniae remains a serious concern worldwide, particularly in Asian countries, despite the introduction of heptavalent pneumococcal conjugate vaccine (PCV7). The Asian Network for Surveillance of Resistant Pathogens (ANSORP) performed a prospective surveillance study of 2,184 S. pneumoniae isolates collected from patients with pneumococcal infections from 60 hospitals in 11 Asian countries from 2008 to 2009. Among nonmeningeal isolates, the prevalence rate of penicillin-nonsusceptible pneumococci (MIC, ≥ 4 µg/ml) was 4.6% and penicillin resistance (MIC, ≥ 8 µg/ml) was extremely rare (0.7%). Resistance to erythromycin was very prevalent in the region (72.7%); the highest rates were in China (96.4%), Taiwan (84.9%), and Vietnam (80.7%). Multidrug resistance (MDR) was observed in 59.3% of isolates from Asian countries. Major serotypes were 19F (23.5%), 23F (10.0%), 19A (8.2%), 14 (7.3%), and 6B (7.3%). Overall, 52.5% of isolates showed PCV7 serotypes, ranging from 16.1% in Philippines to 75.1% in Vietnam. Serotypes 19A (8.2%), 3 (6.2%), and 6A (4.2%) were the most prominent non-PCV7 serotypes in the Asian region. Among isolates with serotype 19A, 86.0% and 79.8% showed erythromycin resistance and MDR, respectively. The most remarkable findings about the epidemiology of S. pneumoniae in Asian countries after the introduction of PCV7 were the high prevalence of macrolide resistance and MDR and distinctive increases in serotype 19A.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Farmacorresistencia Bacteriana / Antibacterianos Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies / Screening_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2012 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones Neumocócicas / Streptococcus pneumoniae / Farmacorresistencia Bacteriana / Antibacterianos Tipo de estudio: Clinical_trials / Observational_studies / Risk_factors_studies / Screening_studies Límite: Humans País/Región como asunto: Asia Idioma: En Revista: Antimicrob Agents Chemother Año: 2012 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos