COPII and the regulation of protein sorting in mammals.
Nat Cell Biol
; 14(1): 20-8, 2011 Dec 22.
Article
en En
| MEDLINE
| ID: mdl-22193160
Secretory proteins are transported to the Golgi complex in vesicles that bud from the endoplasmic reticulum. The cytoplasmic coat protein complex II (COPII) is responsible for cargo sorting and vesicle morphogenesis. COPII was first described in Saccharomyces cerevisiae, but its basic function is conserved throughout all eukaryotes. Nevertheless, the COPII coat has adapted to the higher complexity of mammalian physiology, achieving more sophisticated levels of secretory regulation. In this review we cover aspects of mammalian COPII-mediated regulation of secretion, in particular related to the function of COPII paralogues, the spatial organization of cargo export and the role of accessory proteins.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vesículas Cubiertas por Proteínas de Revestimiento
/
Retículo Endoplásmico
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Vías Secretoras
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Aparato de Golgi
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Cell Biol
Año:
2011
Tipo del documento:
Article
País de afiliación:
Estados Unidos
Pais de publicación:
Reino Unido