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Human immunodeficiency virus-1 B and non-B subtypes with the same drug resistance pattern respond similarly to antiretroviral therapy.
Franzetti, M; Violin, M; Casazza, G; Meini, G; Callegaro, A; Corsi, P; Maggiolo, F; Pignataro, A R; Paolucci, S; Gianotti, N; Francisci, D; Rossotti, R; Filice, G; Carli, T; Zazzi, M; Balotta, C.
Afiliación
  • Franzetti M; Department of Clinical Sciences L. Sacco, Section of Infectious Diseases and Immunopathology, University of Milan, Milan, Italy. marco.franzetti@unimi.it
Clin Microbiol Infect ; 18(3): E66-70, 2012 Mar.
Article en En | MEDLINE | ID: mdl-22192680
We analysed the 12-week virological response to protease inhibitor (PI) or non-nucleoside reverse transcriptase inhibitor (NNRTI) therapy in 1108 patients carrying B or non-B human immunodeficiency virus (HIV)-1 subtypes with matched resistance mutation patterns. Response rates were not significantly different for non-B and B subtypes stratified for treatment status (51.5% vs. 41.5% in naïve patients; 46.7% vs. 38.7% in experienced patients) or regimens (46.9% vs. 39.7% with PI; 56.7% vs. 40% with NNRTI). No difference in response was detected in patients harbouring B and non-B subtypes with any resistance profile. Further studies are advisable to fully test this approach on larger datasets.
Asunto(s)

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Fármacos Anti-VIH / Terapia Antirretroviral Altamente Activa / Farmacorresistencia Viral Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH / VIH-1 / Fármacos Anti-VIH / Terapia Antirretroviral Altamente Activa / Farmacorresistencia Viral Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Clin Microbiol Infect Asunto de la revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Año: 2012 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido