Evaluation of teratogenic effects of risperidone following simultaneous administration with antihypertensive and antiemetic drugs.
Pak J Pharm Sci
; 25(1): 261-6, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22186339
Multiple drug administration is an important aspect of clinical practice particularly in specific physiological situation such as in neonates, elderly or pregnancy, since in all such situations, possibility of unwanted effects increases due to altered body physiology. In present study, the teratogenic effects of multiple drug administration risperidone, meclizine/pyridoxine and hydralazine have been compared with the teratogenic effects of individual drugs in pregnant mice. Moreover the role of folic acid and α-tocopherol if any had also been investigated in reducing the teratogenic effects of these drugs in combinations.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Piridoxina
/
Anomalías Inducidas por Medicamentos
/
Risperidona
/
Alfa-Tocoferol
/
Evaluación Preclínica de Medicamentos
/
Antieméticos
/
Antihipertensivos
Límite:
Animals
Idioma:
En
Revista:
Pak J Pharm Sci
Asunto de la revista:
FARMACIA
/
FARMACOLOGIA
/
QUIMICA
Año:
2012
Tipo del documento:
Article
País de afiliación:
Pakistán
Pais de publicación:
Pakistán