Synthesis of novel 2, 5-dihydrofuran derivatives and evaluation of their anticancer activity.

Zhang, Yikai; Zhong, Hanyu; Wang, Tiantian; Geng, Dongping; Zhang, Mingfeng; Li, Ke

Zhang, Yikai; Zhong, Hanyu; Wang, Tiantian; Geng, Dongping; Zhang, Mingfeng; Li, Ke.

Afiliación

Zhang Y; Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.

Eur J Med Chem ; 48: 69-80, 2012 Feb.

Article en En | MEDLINE | ID: mdl-22182926

RESUMEN

According to metal-catalyzed [3 + 2] cycloaddition reaction, we synthesized a series of novel 2, 5-dihydrofuran derivatives and evaluated their in vitro anti-cancer activities via MTT method. The bioassay showed that the majority of the resultant compounds exerted anti-tumor effect against four human cancer cell lines to various extents, which supported the rationale of the design. Compounds 9e and 10g showed the highest activity with broad anti-cancer spectrum, which were good candidates for further evaluation.

Asunto(s)

Antineoplásicos/síntesis química; Furanos/síntesis química; Antineoplásicos/química; Antineoplásicos/farmacología; Supervivencia Celular/efectos de los fármacos; Furanos/química; Furanos/farmacología; Células HeLa; Humanos; Concentración 50 Inhibidora; Espectroscopía de Resonancia Magnética; Modelos Moleculares; Espectrometría de Masa por Ionización de Electrospray; Espectrofotometría Infrarroja; Relación Estructura-Actividad; Difracción de Rayos X

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Furanos / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2012 Tipo del documento: Article Pais de publicación: Francia

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