Tannic acid suppresses ultraviolet B-induced inflammatory signaling and complement factor B on human retinal pigment epithelial cells.
Cell Immunol
; 273(1): 79-84, 2012.
Article
en En
| MEDLINE
| ID: mdl-22169226
Ultraviolet B (UVB) radiation may cause the inflammation of retinal pigment epithelium (RPE) cells and play a role in development of age-related macular degeneration (AMD). The activation of the complement factor B (CFB) gene has been shown to be involved in formation of AMD. Here our results revealed that UVB induces IL-6/STAT3 signaling activation and the UVB-induced STAT3 is able to regulate the CFB expression in ARPE-19 cells. Tannic acid (TA) is a kind of water-soluble polyphenol and may have anti-inflammation effects. We also found that TA attenuates the UVB-induced IL-6 protein production, the STAT3 phosphorylation and the CFB expression. Taken together, these findings suggest UVB-induced inflammation of RPE can be mediated through the IL-6/STAT3/CFB pathway, and TA has a protected effect via the inhibition to the inflammatory response.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Taninos
/
Rayos Ultravioleta
/
Factor B del Complemento
/
Interleucina-6
/
Factor de Transcripción STAT3
/
Epitelio Pigmentado de la Retina
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Revista:
Cell Immunol
Año:
2012
Tipo del documento:
Article
País de afiliación:
Taiwán
Pais de publicación:
Países Bajos