Defective retrovirus-like 30S RNA species of rat and mouse cells are infectious if packaged by type C helper virus.
J Virol
; 29(3): 964-72, 1979 Mar.
Article
en En
| MEDLINE
| ID: mdl-221684
RNA species with properties of defective retrovirus-like 30S RNA genomes have previously been detected in both rats and mice and in some rat and mouse retroviruses. Using cell lines which express high levels of this retrovirus-like RNA, we formed pseudotypes of the 30S RNAs with helper-independent type C viruses. A pseudotype virus complex containing a mouse 30S subunit was transmitted to rat cells, and a pseudotype virus complex containing a rat 30S subunit was transmitted to bat cells. In other transmission experiments, a rat 30S subunit was isolated in nonproducer bat cells without detectable expression of the helper-independent type C virus used to pseudotype it. The results provide further support for the retrovirus-like nature of the rat 30S subunit and provide evidence which supports the protovirus hypothesis proposed by Temin.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Retroviridae
/
Replicación Viral
/
ARN Viral
/
Virus Helper
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Virus de la Leucemia Murina de Moloney
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
1979
Tipo del documento:
Article
Pais de publicación:
Estados Unidos