Novel PVC-membrane electrode for flow injection potentiometric determination of Biperiden in pharmaceutical preparations.
Talanta
; 87: 40-5, 2011 Dec 15.
Article
en En
| MEDLINE
| ID: mdl-22099646
The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs suspension solution. Electrode matrices were optimized referring to the effect of modifier content and nature, plasticizer and the method of modification. The proposed electrodes work satisfactorily in the BP concentration range from 10(-5) to 10(-2)mol L(-1), with fast response time (7s) and adequate operational lifetime (28 days). The electrode potential is pH independent within the range 2.0-7.0, with good selectivity towards BP in presence of various interfering species. The developed electrodes have been applied for potentiometric determination of BP in pharmaceutical formulation under batch and flow injection analysis (FIA) conditions. FIA offers the advantages of accuracy and automation feasibility with high sampling frequency. The dissolution profile for Akineton tablets (2mg BP/tablet) was studied using the proposed electrode in comparison with the official methods.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cloruro de Polivinilo
/
Potenciometría
/
Preparaciones Farmacéuticas
/
Biperideno
/
Análisis de Inyección de Flujo
/
Antiparkinsonianos
Tipo de estudio:
Diagnostic_studies
/
Evaluation_studies
Idioma:
En
Revista:
Talanta
Año:
2011
Tipo del documento:
Article
País de afiliación:
Egipto
Pais de publicación:
Países Bajos