Evaluating the effect of various background correction methods regarding noise reduction, in two-channel microarray data.
Comput Biol Med
; 42(1): 19-29, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-22074762
In this work, two novel background correction (BC) methods, along with several commonly used ones, are evaluated regarding noise reduction in eleven two-channel self-versus-self (SVS) hybridizations. The evaluation of each BC method is investigated under the use of four statistical criteria combined into a single measure, the polygon area measure. Overall, our proposed BC approaches perform very well in terms of the proposed measure for most of the cases and provide an improved effect regarding technical noise reduction.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Interpretación Estadística de Datos
/
Biología Computacional
/
Análisis de Secuencia por Matrices de Oligonucleótidos
/
Perfilación de la Expresión Génica
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Comput Biol Med
Año:
2012
Tipo del documento:
Article
País de afiliación:
Grecia
Pais de publicación:
Estados Unidos