[Combined radiotherapy-chemotherapy in inoperable bronchial carcinoma (small cell carcinoma excluded)]. / Les associations radiothérapie-chimiothérapie dans les carcinomes bronchiques (à l'exclusion des formes à petites cellules) inopérables.
Bull Cancer
; 77(8): 759-67, 1990.
Article
en Fr
| MEDLINE
| ID: mdl-2207365
When treated by irradiation alone, non small cell carcinomas of the lung usually experience a very poor outcome. Consequently, more interest is being focussed on radiotherapy and chemotherapy association. The analysis of a randomized trial comparing irradiation alone to a sequential or an alternated combination of radio and chemotherapy did not reveal any clear advantage of the association of both therapies on each technique used alone. It is only when using concurrent irradiation and chemotherapy that some encouraging results are reported. Several non randomized studies used radio and chemotherapy prior to surgery, aiming at increasing the resectability rate. However, the criteria for initial unresectability were not homogeneous and it is not yet clear if such an association really allowed the state of surgical resection to be improved. In the near future it could be worth considering the use of radiosensitizing drugs, synchroneously given with an irradiation delivered with a multiple daily fractionation. This technique would possibly lead to a therapeutic gain, by increasing the local control rate and reducing the metastasis rate, while keeping it to an acceptable level of toxicity.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma Broncogénico
/
Neoplasias Pulmonares
Tipo de estudio:
Clinical_trials
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
Fr
Revista:
Bull Cancer
Año:
1990
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Francia