Clinical and laboratory outcomes during the treatment of rheumatoid arthritis with methotrexate.

Cannon, G W; Reading, J C; Ward, J R; Blonquist, L J; Collette, L B

Cannon, G W; Reading, J C; Ward, J R; Blonquist, L J; Collette, L B.

Afiliación

Cannon GW; Department of Internal Medicine, University of Utah School of Medicine, Salt Lake City.

Scand J Rheumatol ; 19(4): 285-94, 1990.

Article en En | MEDLINE | ID: mdl-2205907

RESUMEN

Ten clinical and three laboratory outcomes were evaluated in 86 patients completing a double-blind placebo-controlled trial of methotrexate in rheumatoid arthritis. The improvement in all measured outcomes was statistically significantly better in patients receiving methotrexate than in patients receiving placebo. The correlations of the changes in outcome measures were calculated to determine if improvement in one parameter was associated with improvement in other clinical parameters. Associations between different clinical outcomes were often statistically significant. Associations between laboratory outcomes were also often statistically significant. However, the association between clinical outcomes and laboratory outcomes was generally poor.

Asunto(s)

Artritis Reumatoide/tratamiento farmacológico; Metotrexato/uso terapéutico; Artritis Reumatoide/metabolismo; Artritis Reumatoide/patología; Proteína C-Reactiva/metabolismo; Método Doble Ciego; Edema/patología; Técnica del Anticuerpo Fluorescente; Humanos; Pruebas de Fijación de Látex; Pronóstico; Ensayos Clínicos Controlados Aleatorios como Asunto; Factor Reumatoide/metabolismo

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Metotrexato Tipo de estudio: Clinical_trials / Prognostic_studies Límite: Humans Idioma: En Revista: Scand J Rheumatol Año: 1990 Tipo del documento: Article Pais de publicación: Reino Unido

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