Apoptosis of peripheral blood mononuclear cells in children exposed to arsenic and fluoride.
Environ Toxicol Pharmacol
; 32(3): 399-405, 2011 Nov.
Article
en En
| MEDLINE
| ID: mdl-22004959
In this study, we evaluated apoptosis induction in human immune cells in children exposed to arsenic (As) and fluoride (F). Children living in two areas in Mexico (Soledad de Graciano Sanchez (SGS) in San Luis Potosí and Colonia 5 de Febrero in Durango) were studied. Water, urine and blood samples were collected. Approximately 90% of the water samples in 5 de Febrero had As and F levels above the World Health Organization intervention guideline (10 µg/L and 1.5mg/L, respectively). In SGS, 0% of the water samples exceeded Mexican guidelines. Urinary As and F levels in children living in 5 de Febrero were significantly higher than the levels found in children living in SGS. In addition, the level of apoptosis was higher in children from the 5 de Febrero community when compared with the level of apoptosis in children living in SGS. Thus, in a worldwide context, our study demonstrates the health risks to children living in these regions.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arsénico
/
Contaminantes Químicos del Agua
/
Leucocitos Mononucleares
/
Apoptosis
/
Fluoruros
Tipo de estudio:
Guideline
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País/Región como asunto:
Mexico
Idioma:
En
Revista:
Environ Toxicol Pharmacol
Año:
2011
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Países Bajos