Your browser doesn't support javascript.
loading
Serum zinc and copper status in Iranian patients with pemphigus vulgaris.
Yazdanpanah, Mohammad Javad; Ghayour-Mobarhan, Majid; Taji, Alireza; Javidi, Zari; Pezeshkpoor, Fakhrozaman; Tavallaie, Shima; Momenzadeh, Akram; Esmaili, Habibollah; Shojaie-Noori, Saber; Khoddami, Mohsen; Sahebkar, Amirhossein.
Afiliación
  • Yazdanpanah MJ; Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Faculty of Medicine.
  • Ghayour-Mobarhan M; Department of Nutrition, Faculty of Medicine.
  • Taji A; Cardiovascular Research Center, Avicenna Research Institute.
  • Javidi Z; Health Center, Faculty of Medicine.
  • Pezeshkpoor F; Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Faculty of Medicine.
  • Tavallaie S; Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Faculty of Medicine.
  • Momenzadeh A; Cardiovascular Research Center, Avicenna Research Institute.
  • Esmaili H; Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Faculty of Medicine.
  • Shojaie-Noori S; Department of Community Medicine and Public Health, Faculty of Medicine, , Mashhad University of Medical Sciences (MUMS), Mashhad, Iran.
  • Khoddami M; Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Faculty of Medicine.
  • Sahebkar A; Research Center for Skin Diseases and Cutaneous Leishmaniasis, Department of Dermatology, Ghaem Hospital, Faculty of Medicine.
Int J Dermatol ; 50(11): 1343-1346, 2011 Nov.
Article en En | MEDLINE | ID: mdl-22004485
BACKGROUND: The role of nutritional factors including trace elements has been reported in the pathogenesis of many autoimmune diseases. OBJECTIVE: Regarding the relatively high prevalence of pemphigus vulgaris in Iran, we investigated the serum levels of zinc and copper as two important trace elements, together with the oxidative stress status in patients with pemphigus vulgaris. MATERIALS AND METHODS: This case-control study was performed on 25 patients with newly diagnosed pemphigus vulgaris and 25 age- and sex-matched healthy control subjects. Serum concentrations of zinc, copper, ceruloplasmin as well as copper/zinc ratio were determined for each subject. Oxidative stress was also measured using a novel assay of peroxidant-antioxidant balance (PAB). RESULTS: Mean serum concentrations of zinc and copper as well as copper/zinc ratio were significantly lower in patients (mean age: 47.2±16.2 years; male/female: 14/11) compared with the controls (mean age: 47.3±12.8 years; male/female: 14/11; P<0.001). In contrast, PAB values were significantly elevated in patients compared with controls (P<0.01). No significant difference in serum ceruloplasmin concentrations was observed between the groups (P>0.05). CONCLUSION: Our findings indicate that low serum zinc and copper and increased oxidative stress may be associated with pemphigus vulgaris.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zinc / Pénfigo / Estrés Oxidativo / Cobre Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Dermatol Año: 2011 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Zinc / Pénfigo / Estrés Oxidativo / Cobre Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Int J Dermatol Año: 2011 Tipo del documento: Article Pais de publicación: Reino Unido