DHA supplementation during pregnancy and lactation affects infants' cellular but not humoral immune response.
Mediators Inflamm
; 2011: 493925, 2011.
Article
en En
| MEDLINE
| ID: mdl-21941411
BACKGROUND: It is currently recommended that diet of pregnant mothers contain 200-300 mg DHA/day. Aim. To determine whether DHA supplementation during pregnancy and lactation affects infants' immune response. METHODS: 60 women in ≥3rd pregnancy studied; 30 randomly assigned to receive DHA 400 mg/day from 12th week gestation until 4 months postpartum. From breast-fed infants, blood obtained for anti-HBs antibodies, immunoglobulins, lymphocyte subset phenotyping, and intracellular cytokine production. RESULTS: CD4+ lymphocytes did not differ between groups, but CD4CD45RA/CD4 (naïve cells) significantly higher in infants in DHA+ group. Proportion of CD4 and CD8 cells producing IFN(γ) significantly lower in DHA+ group, with no differences in proportion of IL4-producing cells. Immunoglobulins and anti-HBs levels did not differ between groups. CONCLUSIONS: In infants of mothers receiving DHA supplementation, a higher percentage of CD4 naïve cells and decreased CD4 and CD8 IFN(γ) production is compatible with attenuation of a proinflammatory response.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Lactancia Materna
/
Lactancia
/
Ácidos Docosahexaenoicos
/
Suplementos Dietéticos
/
Inmunidad Humoral
/
Inmunidad Celular
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Infant
/
Pregnancy
Idioma:
En
Revista:
Mediators Inflamm
Asunto de la revista:
BIOQUIMICA
/
PATOLOGIA
Año:
2011
Tipo del documento:
Article
País de afiliación:
Israel
Pais de publicación:
Estados Unidos