Y-autosome translocation interferes with meiotic sex inactivation and expression of autosomal genes: a case study in the pig.
Sex Dev
; 6(1-3): 143-50, 2012.
Article
en En
| MEDLINE
| ID: mdl-21921590
Y-autosome translocations are rare in humans and pigs. In both species, these rearrangements can be responsible for meiotic arrest and subsequent infertility. Chromosome pairing abnormalities on the SSCX, SSCY and SSC1 chromatin domains were identified by analyzing pachytene spermatocytes from a boar carrying a (Y;1) translocation by immunolocalization of specific meiotic protein combined with FISH. Disturbance of the meiotic sex chromosome inactivation (MSCI) was observed by Cot-RNA-FISH and analysis of ZFY gene expression by sequential RNA- and DNA-FISH on spermatocytes. We hypothesized that the meiotic arrest observed in this boar might be due to the silencing of critical autosomal genes and/or the reactivation of some sex chromosome genes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades de los Porcinos
/
Translocación Genética
/
Cromosoma X
/
Cromosoma Y
/
Silenciador del Gen
/
Meiosis
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Sex Dev
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
Año:
2012
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Suiza