Neuroleptic malignant syndrome in adolescents: four probable cases in the Western Cape.
S Afr Med J
; 101(6): 405-7, 2011 May 25.
Article
en En
| MEDLINE
| ID: mdl-21920075
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a rare side-effect of neuroleptic medication. Most NMS reports have been on adults, and the incidence in children and adolescents is unknown. OBJECTIVE: This report reviews cases of NMS to highlight possible risk factors for the development of NMS in adolescents. METHOD: Four cases of probable NMS in adolescents diagnosed in the Western Cape between February 2009 and March 2010 are presented. RESULTS: Risk factors in the development of the syndrome in adolescents in the Western Cape may be male gender, polypharmacy, the use of zuclopenthixol acetate (clopixol acuphase), a previous history of extra-pyramidal side-effects or NMS, and a history of substance misuse - in particular methamphetamine. CONCLUSION: Caution must be applied in the apparent overuse of intramuscular antipsychotics, and especially zuclopenthixol acetate (clopixol acuphase), in neuroleptic-naïve and agitated psychotic adolescents where the short-term use of benzodiazepines is more appropriate.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Síndrome Neuroléptico Maligno
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Humans
/
Male
País/Región como asunto:
Africa
Idioma:
En
Revista:
S Afr Med J
Año:
2011
Tipo del documento:
Article
Pais de publicación:
Sudáfrica