The Philadelphia translocation in CML and ALL: recent investigations, new detection methods.

Hagemeijer, A; van der Plas, D C; Soekarman, D; van Denderen, J; Grosveld, G

Hagemeijer, A; van der Plas, D C; Soekarman, D; van Denderen, J; Grosveld, G.

Afiliación

Hagemeijer A; Department of Cell Biology and Genetics, Erasmus University, Rotterdam, The Netherlands.

Nouv Rev Fr Hematol (1978) ; 32(1): 83-6, 1990.

Article en En | MEDLINE | ID: mdl-2190182

RESUMEN

As a consequence of the Ph translocation, a bcr-abl fusion gene is formed that encodes chimeric bcr-abl proteins. The latter are probably causally involved in leukemogenesis, although the mechanism is not yet known. Meanwhile, the heterogeneous aspects of the Ph translocation have been explored in an effort to disclose their eventual clinical significance. Innovative and useful methods have been devised for the detection of the Ph translocation products e.g. the PCR technique or the production of specific antibodies that undoubtedly will prove to be of great help to patients and clinicians in future.

Asunto(s)

Leucemia Mielógena Crónica BCR-ABL Positiva/genética; Leucemia-Linfoma Linfoblástico de Células Precursoras/genética; Translocación Genética/genética; Mapeo Cromosómico; Humanos; Pruebas Inmunológicas; Leucemia Mieloide Crónica Atípica BCR-ABL Negativa/genética; Reacción en Cadena de la Polimerasa; Proto-Oncogenes/fisiología

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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Translocación Genética / Leucemia Mielógena Crónica BCR-ABL Positiva / Leucemia-Linfoma Linfoblástico de Células Precursoras Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Nouv Rev Fr Hematol (1978) Año: 1990 Tipo del documento: Article País de afiliación: Países Bajos Pais de publicación: Alemania

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