[SOS response of DNA repair and genetic cell instability under hypoxic conditions].
Radiats Biol Radioecol
; 51(3): 321-7, 2011.
Article
en Ru
| MEDLINE
| ID: mdl-21866831
The SOS DNA repair pathway is induced in E. coli as a multifunctional cell response to a wide variety of signals: UV, X or gamma-irradiation, mitomycin C or nalidixic acid treatment, thymine starvation, etc. Triggering of the system can be used as a general and early sign of DNA damage. Additionally, the SOS-response is known to be an "error-prone" DNA repair pathway and one of the sources of genetic instability. Hypoxic conditions are established to be the major factor of genetic instability as well. In this paper we for the first time studied the SOS DNA repair response under hypoxic conditions induced by the well known aerobic SOS-inducers. The SOS DNA repair response was examined as a reaction of E. coli PQ37 [sfiA::lacZ] cells to UVC, NO-donating agents and 4NQO. Here we provide evidence that those agents were able to induce the SOS DNA repair response in E. coli at anaerobic growth conditions. The process does not depend on the transcriptional activity of the universal protein of E. col anaerobic growth Fnr [4Fe-4S]2+ or can not be referred to as an indicator of genetic instability in hypoxic conditions.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxígeno
/
Daño del ADN
/
Respuesta SOS en Genética
/
Proteínas de Escherichia coli
/
Escherichia coli
Idioma:
Ru
Revista:
Radiats Biol Radioecol
Asunto de la revista:
GENETICA
/
MEDICINA NUCLEAR
Año:
2011
Tipo del documento:
Article
Pais de publicación:
Rusia