Biphasic dose-response of antioxidants in hypericin-induced photohemolysis.
Photodiagnosis Photodyn Ther
; 8(3): 282-7, 2011 Sep.
Article
en En
| MEDLINE
| ID: mdl-21864803
In the present paper the photodynamic effect of hypericin on superoxide dismutase activity and the possibility of reduction of hypericin phototoxicity by antioxidants were studied. It was shown an almost twice decrease in superoxide dismutase activity of red blood cells under the photosensitization by hypericin. The influence of antioxidants (ascorbic acid and quercetin) on hypericin photodynamic action has revealed that these antioxidants suppress or stimulate photohemolysis caused by hypericin. The photosensitization reaction realized by hypericin could be shifted from type II to type I or vice versa by manipulating the antioxidant concentration. Strengthening of photohemolysis by antioxidants in some concentrations indicates the switching of alternative mechanisms of hypericin photodynamic action and its complicated manner. Thus the selection of antioxidant concentrations is of extreme importance for changing the efficacy of photodynamic therapy with hypericin.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Perileno
/
Proteína Quinasa C
/
Canales de Calcio
/
Fármacos Fotosensibilizantes
/
Hemólisis
/
Antioxidantes
Límite:
Humans
/
Male
Idioma:
En
Revista:
Photodiagnosis Photodyn Ther
Asunto de la revista:
DIAGNOSTICO POR IMAGEM
/
TERAPEUTICA
Año:
2011
Tipo del documento:
Article
Pais de publicación:
Países Bajos