Amplification of the c-myc oncogene during progression of radiation-induced rat skin tumors.
Cancer Res
; 50(10): 3073-7, 1990 May 15.
Article
en En
| MEDLINE
| ID: mdl-2185880
Evaluation of a large panel of radiation-induced rat skin tumors of diverse size and histological type revealed a correlation between c-myc copy number and tumor size. Both the frequency and degree of c-myc gene amplification were increased in large compared to small carcinomas, but none of the sarcomas examined showed c-myc amplification. Serial biopsies of individual tumors exhibited similar trends of increasing c-myc copy number in later biopsies. In one regressing tumor, the c-myc gene copy number paralleled the growth rate of the tumor during growth and regression. The average time required from tumor appearance to significant gene amplification was close to the average period between tumor appearance and the onset of rapid growth. The data suggest that, rather than being a target gene for the direct early effects of ionizing radiation, c-myc functions as a late-stage progression-related oncogene in this model system.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oncogenes
/
Neoplasias Cutáneas
/
ADN de Neoplasias
/
Carcinoma
/
Amplificación de Genes
/
Proteínas Proto-Oncogénicas
/
Neoplasias Inducidas por Radiación
Tipo de estudio:
Diagnostic_studies
/
Prognostic_studies
Límite:
Animals
Idioma:
En
Revista:
Cancer Res
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Estados Unidos