The insecticide DDT targets the OSCP and subunit D of the Apis mellifera ATP synthase.
J Bioenerg Biomembr
; 43(5): 457-63, 2011 Oct.
Article
en En
| MEDLINE
| ID: mdl-21847589
1,1-bis (p-chlorophenyl)-2, 2, 2-trichloroethane (DDT) has been used for control of malaria mosquitoes and other insect vectors of human diseases since 1945. Its use poses an environmental dilemma and efforts to replace it have been hampered by lack of information about its molecular target. This work identifies the 23 kDa band responsible for the DDT sensitivity in bees, as the OSCP and subunit "d" of the ATP synthase. The OSCP of the bee's ATP synthase contained 207 amino acids compared to 190 in bovine, which is insensitive to DDT, and the identities were only 47%. Subunit "d" of the bees had no counterpart in the bovine. Whether DDT is interacting only with OSCP, only with subunit "d", or with both subunits, remains to be assessed. Identification of the molecular target of DDT will lead the way to new target based insecticides aimed to protect plant, combat malaria and other insect transmitted diseases.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Abejas
/
Proteínas de Insectos
/
ATPasas de Translocación de Protón Mitocondriales
/
DDT
/
Insecticidas
Límite:
Animals
/
Humans
Idioma:
En
Revista:
J Bioenerg Biomembr
Año:
2011
Tipo del documento:
Article
País de afiliación:
Egipto
Pais de publicación:
Estados Unidos