PURPOSE: The objective of this study was to compare the clinical and histologic peri-implant parameters of a nano-calcium phosphate (CaP)-coated dual acid-etched (DAE) implant (n = 7) to those of an uncoated DAE implant (n = 7). MATERIALS AND METHODS: The study included seven dogs who received implants bilaterally in edentulous mandibular areas; in the right side, procedures were performed 8 months after procedures in the left mandible. Clinical parameters were measured prior to euthanasia (8 months after the second set of implants was placed), followed by histologic nondecalcified processing for morphometric evaluation. Bone-implant contact (BIC), crestal bone resorption (CBR), intrabony defect (IBD), and bone area fraction (BAF) were measured. Analysis of variance with repeated measures and a two-tailed Pearson correlation test were applied. RESULTS: Probing depth, Bleeding Index, and keratinized mucosal height were stable in both groups; there was a significant improvement in probing depths with time (P = .014). Morphometric measurements showed BIC from 75% to 89% in both groups at 8 and 16 months. The nano-CaP-coated group (n-CaP) showed a significant increase in BIC over time when compared to the DAE group (P = .02). Crestal bone level was maintained in both groups with average resorption of 1.4 to 1.5 mm at the n-CaP implants and 1.1 to 1.2 mm at the DAE implants at 8 and 16 months, respectively. Mean IBD values were 0.88 to 1.18 mm at the n-CaP implants and 0.65 to 0.66 mm at the DAE implants at the respective periods. CONCLUSIONS: Within the limitations of this study, both the DAE and the n-CaP-surface implants showed successful osseointegration and functional soft and hard tissue adaptation. Except for the significant increase in BIC around the n-CaP implants over time, both showed similar clinical and histologic findings.