Your browser doesn't support javascript.
loading
Attenuation of ERK/RSK2-driven NFκB gene expression and cancer cell proliferation by kurarinone, a lavandulyl flavanone isolated from Sophora flavescens ait. roots.
Berghe, Wim Vanden; De Naeyer, An; Dijsselbloem, Nathalie; David, Jean-Pierre; De Keukeleire, Denis; Haegeman, Guy.
Afiliación
  • Berghe WV; Ghent University (UGent), Department of Physiology, Laboratory of Eukaryotic Gene Expression and Signal Transduction, Ledeganckstraat, Ghent, Belgium. wim.vandenberghe@ua.ac.be
Endocr Metab Immune Disord Drug Targets ; 11(3): 247-61, 2011 Sep 01.
Article en En | MEDLINE | ID: mdl-21831037
We have analyzed in molecular detail how kurarinone, a lavandulyl flavanone isolated from Sophora flavescens, suppresses nuclear factor-κB (NFκB)-driven interleukin-6 (IL6) expression and cancer cell growth. Interleukin-6 (IL6), involved in cancer-related inflammation, acts as an autocrine and paracrine growth factor, which promotes angiogenesis, metastasis, and subversion of immunity, and changes responsivity to hormones and to chemotherapeutics. Our results in estrogen-unresponsive fibroblasts, ribosomal S6 kinase 2 kinase (RSK2) knockout cells, and estrogen receptor (ER)-deficient breast tumor cells show that kurarinone can inhibit tumor cell proliferation and selectively block nuclear NFκB transactivation of specific target genes such as IL6, cyclin D1, SOD2 but not TNFAIP2. This occurs via attenuation of extracellular signal-regulated protein (ERK) and RSK2 kinase pathways and inhibition of S6 kinase ribosomal protein (S6RP) and histone H3 S10 phosphorylation. As constitutive NFκB and RSK2 activity are important hallmarks of human cancers, including hematopoietic malignancies and solid tumors, prenylated flavanones represent an attractive class of natural inhibitors of the ERK/RSK2 signaling pathway for cancer therapy.
Asunto(s)
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Neoplasias de la Mama / Regulación Enzimológica de la Expresión Génica / Proteínas Serina-Treonina Quinasas / Sophora / Proteínas Quinasas S6 Ribosómicas 90-kDa / Quinasas MAP Reguladas por Señal Extracelular Límite: Animals / Female / Humans Idioma: En Revista: Endocr Metab Immune Disord Drug Targets Asunto de la revista: ALERGIA E IMUNOLOGIA / ENDOCRINOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Año: 2011 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Emiratos Árabes Unidos
Buscar en Google
Añadir a Mi BVS
Imprimir
XML
PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Neoplasias de la Mama / Regulación Enzimológica de la Expresión Génica / Proteínas Serina-Treonina Quinasas / Sophora / Proteínas Quinasas S6 Ribosómicas 90-kDa / Quinasas MAP Reguladas por Señal Extracelular Límite: Animals / Female / Humans Idioma: En Revista: Endocr Metab Immune Disord Drug Targets Asunto de la revista: ALERGIA E IMUNOLOGIA / ENDOCRINOLOGIA / METABOLISMO / TERAPIA POR MEDICAMENTOS Año: 2011 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Emiratos Árabes Unidos