Contiguous bilateral head and neck paragangliomas in a carrier of the SDHB germline mutation.
J Vasc Surg
; 55(1): 216-9, 2012 Jan.
Article
en En
| MEDLINE
| ID: mdl-21820839
Paragangliomas are extremely rare neoplasms with multicentric presentation usually linked to familial tumor syndromes. This patient presented with the uncommon combination of concurrent bilateral carotid body tumors and a unilateral glomus jugulare mass that demonstrated vascular continuity. During treatment, the patient was found to be heterozygous for the SDHB germline mutation, an autosomal dominant genotype of the familial paraganglioma syndromes associated with increased malignancy. The unique profile of the SDHB patient as regards primary evaluation, surgical considerations, and extended surveillance was explored and has led to a proposed treatment algorithm for these patients.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Succinato Deshidrogenasa
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Tumor del Cuerpo Carotídeo
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Tumor del Glomo Yugular
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Mutación
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Neoplasias Primarias Múltiples
Límite:
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Vasc Surg
Asunto de la revista:
ANGIOLOGIA
Año:
2012
Tipo del documento:
Article
Pais de publicación:
Estados Unidos