[Effect of acetylsalicylic acid in complex with lipid nanostructures of various compositions on human platelet aggregation].
Eksp Klin Farmakol
; 74(5): 31-4, 2011.
Article
en Ru
| MEDLINE
| ID: mdl-21809695
The effect of lipid nanocomplexes loaded with acetylsalicylic acid (aspirin) on platelet aggregation in vitro was investigated. The antithrombotic effect of aspirin in complex with liposomes prepared from pig brain glycosphingolipids is not only significantly higher compared to control, but also accompanied by leveling of the development of proaggregant effects. It was shown that ADP-induced platelet aggregation is reduced by the introduction of electrostatic charge in the structure of lipid bilayer of liposomes. The effect achieved for the liposomes possessing a negative charge was more pronounced in comparison to the effect of positively charged liposomes.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Plaquetas
/
Inhibidores de Agregación Plaquetaria
/
Glicoesfingolípidos
/
Trastornos Cerebrovasculares
/
Agregación Plaquetaria
/
Aspirina
/
Liposomas
Límite:
Animals
/
Humans
Idioma:
Ru
Revista:
Eksp Klin Farmakol
Asunto de la revista:
FARMACOLOGIA
Año:
2011
Tipo del documento:
Article
Pais de publicación:
Rusia