A double-blind comparison of the efficacy and acceptability of Femodene and Microgynon-30.
Eur J Obstet Gynecol Reprod Biol
; 34(3): 257-66, 1990 Mar.
Article
en En
| MEDLINE
| ID: mdl-2178992
The efficacy, cycle-control and tolerance of Microgynon-30, a widely prescribed levonorgestrel containing oral contraceptive, and Femodene, a new oral-contraceptive containing gestodene, were compared in a randomised, double-blind study involving 456 healthy women over a 6 month period. 229 women were allocated to receive Femodene and 227 received Microgynon-30. No differences between the groups in terms of obstetric and gynaecological history, previous contraceptive history, smoking habits, blood-pressure or body weight at admission were observed. No pregnancies were reported in either group, despite tablet-taking errors recorded in 6.3% of the Femodene group and 7.6% of the Microgynon-30 group. Both oral contraceptives were compared in terms of cycle length, intensity of the withdrawal bleed and side effects. Cycle-control was similar in the two groups. However, significantly fewer subjects reported breakthrough bleeding (with or without spotting) in the Femodene group (18% of patients) compared with the Microgynon-30 group (26% of patients). The incidence of absent withdrawal bleeds was 1% or less in both groups and no significant effects on body weight or blood pressure were observed.
Palabras clave
Acceptor Characteristics; Acceptors; Biology; Bleeding; Blood Pressure--changes; Body Weight--changes; Contraception; Contraceptive Methods--side effects; Contraceptive Usage; Developed Countries; Diseases; Double-blind Studies; Europe; Evaluation; Family Planning; Family Planning Programs; Hemic System; Incidence; Measurement; Menstrual Cycle; Menstruation; Method Acceptability; Northern Europe; Oral Contraceptives--side effects; Physiology; Reproduction; Research Methodology; Signs And Symptoms; Studies; United Kingdom
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Anticonceptivos Orales Combinados
/
Etinilestradiol
/
Norgestrel
/
Norpregnenos
Tipo de estudio:
Clinical_trials
Límite:
Adolescent
/
Adult
/
Female
/
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Eur J Obstet Gynecol Reprod Biol
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Irlanda