Effect of acyclovir on herpes simplex virus infected neuronal, glial, and neurohybridoma cells in vitro.
Intervirology
; 31(5): 285-9, 1990.
Article
en En
| MEDLINE
| ID: mdl-2177046
Herpesvirus type 1 could be propagated most efficiently in cultured fetal neurons, to a lesser extent in NG108-15 neurohybridoma cells, and with the lowest titer in glial cells. Herpesvirus type 2 could not be cultured in neurohybridoma cells, and in fetal neurons a titer 100-fold lower than for herpesvirus type 1 was obtained. Cells infected with herpesvirus type 1 were used in an infectivity assay for acyclovir dose-response studies. The ED50 values were 7.4 nmol/l for fetal neurons, 180 for neurohybridoma cells, and 275 nmol/l for glial cells.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Aciclovir
/
Neuroglía
/
Simplexvirus
/
Neuronas
Límite:
Animals
Idioma:
En
Revista:
Intervirology
Año:
1990
Tipo del documento:
Article
Pais de publicación:
Suiza