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Effect of acyclovir on herpes simplex virus infected neuronal, glial, and neurohybridoma cells in vitro.
Borcholte, T; Kliem, V; Verhagen, W; Wellhöner, H H.
Afiliación
  • Borcholte T; Deutsche Wellcome GmbH, Burgwedel, FRG.
Intervirology ; 31(5): 285-9, 1990.
Article en En | MEDLINE | ID: mdl-2177046
Herpesvirus type 1 could be propagated most efficiently in cultured fetal neurons, to a lesser extent in NG108-15 neurohybridoma cells, and with the lowest titer in glial cells. Herpesvirus type 2 could not be cultured in neurohybridoma cells, and in fetal neurons a titer 100-fold lower than for herpesvirus type 1 was obtained. Cells infected with herpesvirus type 1 were used in an infectivity assay for acyclovir dose-response studies. The ED50 values were 7.4 nmol/l for fetal neurons, 180 for neurohybridoma cells, and 275 nmol/l for glial cells.
Asunto(s)
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aciclovir / Neuroglía / Simplexvirus / Neuronas Límite: Animals Idioma: En Revista: Intervirology Año: 1990 Tipo del documento: Article Pais de publicación: Suiza
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aciclovir / Neuroglía / Simplexvirus / Neuronas Límite: Animals Idioma: En Revista: Intervirology Año: 1990 Tipo del documento: Article Pais de publicación: Suiza