Proteomic analysis of an Aedes albopictus cell line infected with Dengue serotypes 1 and 3 viruses.
Parasit Vectors
; 4: 138, 2011 Jul 18.
Article
en En
| MEDLINE
| ID: mdl-21767351
BACKGROUND: Proteomic analysis was performed to identify proteins regulated during infection by Dengue serotypes 1 and 3 in an Aedes albopictus cell line. The potential of these viruses to cause severe disease at primary infection is of interest although few studies have been performed with these two Dengue serotypes. RESULTS: The most relevant observation of our study is the significant overexpression of proteins involved in the cellular stress response and the glycolysis pathway after 48 hours of infection. Viral infection activates the translation of some host genes, which may result in stress due to responses involving unfolded proteins. CONCLUSIONS: Therefore, the oxidation reduction and glycolytic mechanisms could participate in the antiviral response against Dengue virus. The results of our study should help to improve our knowledge of the virus-mosquito interaction at a cellular level with the aim of designing efficient strategies for the control of Dengue virus.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas de Insectos
/
Aedes
/
Proteoma
/
Virus del Dengue
Límite:
Animals
Idioma:
En
Revista:
Parasit Vectors
Año:
2011
Tipo del documento:
Article
País de afiliación:
Francia
Pais de publicación:
Reino Unido