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Bilirubin dependence on UGT1A1 polymorphisms, hemoglobin, fasting time and body mass index.
Rodrigues, Carina; Costa, Elísio; Vieira, Emília; Santos, Rosário; De Carvalho, João; Rocha-Pereira, Petronila; Santos-Silva, Alice; Bronze-da-Rocha, Elsa.
Afiliación
  • Rodrigues C; Department of Biological Sciences, Biochemistry Laboratory, Faculty of Pharmacy of Oporto University, Porto; Health College of Polytechnic Institute of Bragança, Bragança.
  • Costa E; Institute of Health Sciences of Portuguese Catholic, Porto; Institute for Cellular and Molecular Biology, Oporto University, Porto, Portugal.
  • Vieira E; Molecular Genetics Unit, Institute of Medical Genetics Dr. Jacinto Magalhães INSARJ, Porto.
  • Santos R; Molecular Genetics Unit, Institute of Medical Genetics Dr. Jacinto Magalhães INSARJ, Porto.
  • De Carvalho J; Gastroenterology Department, Centro Hospitalar de Vila Nova de Gaia.
  • Rocha-Pereira P; Investigation Center for Health Sciences, University of Beira Interior, Covilhã.
  • Santos-Silva A; Department of Biological Sciences, Biochemistry Laboratory, Faculty of Pharmacy of Oporto University, Porto; Institute for Cellular and Molecular Biology, Oporto University, Porto, Portugal.
  • Bronze-da-Rocha E; Department of Biological Sciences, Biochemistry Laboratory, Faculty of Pharmacy of Oporto University, Porto; Institute for Cellular and Molecular Biology, Oporto University, Porto, Portugal. Electronic address: elsa.rocha@ff.up.pt.
Am J Med Sci ; 343(2): 114-118, 2012 Feb.
Article en En | MEDLINE | ID: mdl-21760472
In humans, bilirubin levels are influenced by different factors. This study evaluates how several nongenetic causes and the genetic UGT1A1 polymorphisms contribute for bilirubin levels, in a cohort of 146 young Caucasian females. Hematological data, bilirubin, screening of TA duplication in the UGT1A1 gene, body mass index (BMI) and body fat were determined. A questionnaire about fasting time, smoking habits, oral contraceptive therapy, caloric intake and physical activity was done. Participants were divided according to the tertiles of bilirubin. Subjects from the second and third tertile had significant rises in hemoglobin (Hb), hematocrit, mean cell Hb and mean cell Hb concentration, and a significant increased frequency for the c.-41_-40dupTA allele in homozygosity, when compared to the first tertile. Red blood cell count was significantly increased in the third tertile. Results showed that the c.-41_-40dupTA allele (genetic), Hb, BMI and fasting time (nongenetic) were the main factors associated bilirubin levels.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Hemoglobinas / Índice de Masa Corporal / Ayuno / Glucuronosiltransferasa Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans País/Región como asunto: Europa Idioma: En Revista: Am J Med Sci Año: 2012 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Bilirrubina / Hemoglobinas / Índice de Masa Corporal / Ayuno / Glucuronosiltransferasa Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans País/Región como asunto: Europa Idioma: En Revista: Am J Med Sci Año: 2012 Tipo del documento: Article Pais de publicación: Estados Unidos