Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy.
ACS Nano
; 5(8): 6156-63, 2011 Aug 23.
Article
en En
| MEDLINE
| ID: mdl-21732610
DNA can be used to nanofabricate three-dimensional (3D) polyhedra. A variety of applications of 3D DNA assemblies have been proposed. Drug encasulation and intracellular delivery using DNA nanoparticles, however, have remained a challenge. Here, we create a distinct five-point-star motif and aptamer-conjugated six-point-star motif using well-used primer sequences to intermolecularly construct DNA icosahedra as a nanocarrier for doxorubicin. Aptamer-conjugated doxorubicin-intercalated DNA icosahedra (Doxo@Apt-DNA-icosa) show an efficient and specific internalization for killing epithelial cancer cells.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
ADN
/
Portadores de Fármacos
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Doxorrubicina
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Aptámeros de Nucleótidos
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Nanopartículas
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Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
ACS Nano
Año:
2011
Tipo del documento:
Article
País de afiliación:
Taiwán
Pais de publicación:
Estados Unidos