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[Veto T cells enhance engraftment allogeneic hematopoietic stem cells].
Li, Feng; Duan, Lian-Ning; Ji, Shu-Quan.
Afiliación
  • Li F; Department of Hematolgy, Chinese PLA Air Force General Hospital, Beijing 100142, China; The Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi ; 19(3): 824-7, 2011 Jun.
Article en Zh | MEDLINE | ID: mdl-21729580
Veto activity was defined as the capacity of specifically downregulating cytotoxic T-precursor cell (CTL-p) directed against antigens of the veto cells themselves but not against third-party antigens. Many studies have shown that the most potent veto cells are CD8(+) cytotoxic T lymphocytes (CD8(+)CTLs). Effectively, CD8(+)CTLs of donor origin can facilitate engraftment of donor's stem cells by eliminating host-alloreactive T lymphocytes. In this article, effect mechanisms, depletion of GVH ex vivo, application in vivo, synergistic enhancement with rapamycin and regulatory T cells, and anti-tumor effect in the hematopoietic stem cell transplantation are summarized.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Trasplante de Células Madre Hematopoyéticas Límite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: China Pais de publicación: China
Buscar en Google
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T Citotóxicos / Trasplante de Células Madre Hematopoyéticas Límite: Humans Idioma: Zh Revista: Zhongguo Shi Yan Xue Ye Xue Za Zhi Asunto de la revista: HEMATOLOGIA Año: 2011 Tipo del documento: Article País de afiliación: China Pais de publicación: China